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focused-ultrasound

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Glioblastoma (GBM) remains lethal despite multimodal therapy, with median survival under 15 months. Immunotherapy has failed in over 100 clinical trials due to three fundamental barriers: inadequate immune priming in "cold" tumors, blood–brain barrier (BBB) exclusion of therapeutics, and profound local immunosuppression.

  • Updated Dec 23, 2025
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